Annual report pursuant to Section 13 and 15(d)

Collaboration and License Agreements and Supply Agreements - Additional Information (Details)

v3.24.1
Collaboration and License Agreements and Supply Agreements - Additional Information (Details)
1 Months Ended 12 Months Ended
Nov. 30, 2023
USD ($)
Installment
Oct. 31, 2023
USD ($)
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
PerformanceObligation
Program
Apr. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Mar. 31, 2020
USD ($)
Jul. 31, 2018
USD ($)
Program
Aug. 31, 2017
Program
Dec. 31, 2023
USD ($)
shares
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2021
USD ($)
shares
Apr. 30, 2021
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Accounts receivable, reserve for credit losses                   $ 0 $ 0    
Shares | shares                   167,780 167,780 167,780  
Vaxcyte, Inc.                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
First installment milestone payment received $ 50,000,000                        
Additional milestone payment receivable $ 25,000,000                        
Deferred revenue                   $ 0 $ 17,500,000    
Nonrefundable, non-creditable upfront payment receivable                     10,000,000    
Common stock fair value                     $ 7,500,000    
Payment received from definitive agreement   $ 5,000,000                      
Recognition of up front payment                   97,500,000      
Additional milestone payment                   60,000,000      
Shares | shares                     167,780    
Number of installments | Installment 2                        
Blackstone Life Sciences                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Upfront payment received     $ 140,000,000             140,000,000      
2019 EMD Serono Supply Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue                   0 $ 0    
BMS Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Number of programs advancing through preclinical development | Program                 4        
Deferred revenue                   0 0    
2018 BMS Master Services Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue                   0 3,100,000    
2018 Merck Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue                   $ 0 0    
Milestone payment receivable upon initiation of IND enabling toxicology study                         $ 15,000,000
2018 Merck Agreement | Merck Sharp & Dohme Corp                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Contingent payment received                     10,000,000    
Milestone payment received                     2,500,000    
Additional milestone payment received                     7,500,000    
Number of target programs | Program               2          
Initial transaction price               $ 60,000,000          
Revenue recognition aggregate contingent payments eligible to receive                       $ 500,000,000  
Milestone method revenue recognition description                   If one or more products from the target program is developed for non-oncology or a single indication, the Company will be eligible for reduced aggregate contingent payments. In addition, the Company is eligible to receive tiered royalties ranging from mid-single digit to low teen percentages on the worldwide sales of any commercial products that may result from the collaboration      
First Cytokine-Derivative Program | Merck Sharp & Dohme Corp                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Upfront payment received             $ 5,000,000            
Extended research term             1 year            
2020 Merck Master Services Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue                   $ 0 0    
Supply Agreement | Vaxcyte, Inc.                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Reimbursements expenses accruals                   6,900,000 4,800,000    
Reimbursements expenses                   8,600,000 12,400,000 8,900,000  
Tasly License Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Revenue recognized from contingent payment                   5,000,000      
Income tax charge related to contingent payment                   500,000      
Contingent payment recognized as deferred revenue                   5,000,000      
Withholding tax on deferred revenue                   $ 500,000      
Maximum refund period on termination of study                   30 days      
Minimum term of royalties receivable based on annual net sales           10 years              
Nonrefundable upfront payment receivable           $ 40,000,000           40,000,000  
Maximum potential payments related to development regulatory commercialization contingent payments and milestones         $ 350,000,000 $ 345,000,000           $ 345,000,000  
Reduction of research and development expenses recognized                   $ 0 0    
Initial licensing payment due         25,000,000                
Initial licensing payment in escrow         $ 15,000,000                
Upfront payment revenue recognized                     25,000,000    
Upfront payment withholding tax amount                     2,500,000    
Astellas License and Collaboration Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue                   69,000,000 86,100,000    
Number of target programs | Program       3                  
Upfront payment received                   90,000,000      
Transaction price       $ 90,000,000                  
Nonrefundable, non-creditable upfront payment receivable                     $ 90,000,000    
Number of performance obligations | PerformanceObligation       4                  
Recognition of up front payment       $ 89,100,000                  
Estimated service period       4 years                  
Maximum amount eligible to receive for development, regulatory and commercial milestones for each product candidate                   422,500,000      
Upfront payment revenue not recognized                   $ 32,800,000      
Astellas License and Collaboration Agreement | Future Services on Collaboration Joint Steering Committee ("JSC")                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Recognition of up front payment       $ 900,000                  
2015 License Member | Blackstone Life Sciences | Royalty                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Upfront payment received     $ 140,000,000                    
Revenue interest percentage     4.00%             4.00%