Income Taxes - Schedule of Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands |
Dec. 31, 2022 |
Dec. 31, 2021 |
|---|---|---|
| Deferred tax assets: | ||
| Net operating loss carryforwards | $ 60,952 | $ 67,719 |
| Research and development credits | 40,396 | 31,864 |
| Capatalized research and development expenditure | 24,481 | |
| Accruals and other | 3,849 | 3,973 |
| Operating lease liability | 7,471 | 7,266 |
| Stock based compensation | 4,562 | 3,910 |
| Fixed asset basis | 663 | 1,008 |
| Total deferred tax assets | 142,374 | 115,740 |
| Less: valuation allowance | (131,228) | (100,646) |
| Gross deferred tax assets | 11,146 | 15,094 |
| Deferred tax liabilities: | ||
| Operating lease right-of-use asset | (5,783) | (6,716) |
| Vaxcyte investment | (5,363) | (8,378) |
| Total deferred tax liabilities | (11,146) | (15,094) |
| Total net deferred tax assets | $ 0 | $ 0 |
| X | ||||||||||
- Definition Deferred tax assets fixed assets. No definition available.
|
| X | ||||||||||
- Definition Deferred tax assets operating lease liability. No definition available.
|
| X | ||||||||||
- Definition Deferred tax liabilities operating lease right of use asset. No definition available.
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from in-process research and development costs expensed in connection with a business combination. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
|
| X | ||||||||||
- Definition Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
|
| X | ||||||||||
- Definition Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
|
| X | ||||||||||
- References No definition available.
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from share-based compensation. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
|
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from reserves and accruals. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
|
| X | ||||||||||
- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
|
| X | ||||||||||
- Definition Amount, after deferred tax asset, of deferred tax liability attributable to taxable differences without jurisdictional netting. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
|
| X | ||||||||||
- Definition Amount of deferred tax liability attributable to taxable temporary differences from investments (excludes investments in subsidiaries and equity method investments). No definition available.
|
| X | ||||||||||
- References No definition available.
|