Quarterly report pursuant to Section 13 or 15(d)

Collaboration and License Agreements and Supply Agreements - Additional Information (Details)

v3.22.2.2
Collaboration and License Agreements and Supply Agreements - Additional Information (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Mar. 31, 2021
USD ($)
May 31, 2019
USD ($)
Jun. 30, 2022
USD ($)
Program
PerformanceObligation
Apr. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Oct. 31, 2021
USD ($)
Aug. 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Feb. 29, 2020
USD ($)
Sep. 30, 2019
USD ($)
Jul. 31, 2018
USD ($)
Program
Aug. 31, 2017
Program
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Jun. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Accounts receivable, reserve for credit losses         $ 0               $ 0     $ 0   $ 0
BioNova Option Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue                         0     0    
Initial licensing option payment           $ 4,000,000.0             4,000,000.0          
Maximum potential payments related to option exercise, development, regulatory, and commercial milestones           $ 200,000,000                        
Minimum term of royalties receivable based on annual net sales           10 years                        
Initial licensing option refundable payment           $ 4,000,000.0                        
Additional payment required to exercise license option           $ 12,000,000.0                        
BMS Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Number of programs advancing through preclinical development | Program                       4            
Contingent payments   $ 275,000,000.0                                
Deferred revenue         0               0     0   0
2018 BMS Master Services Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         600,000               2,100,000     2,100,000   600,000
2018 Merck Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         900,000               0     0   900,000
Milestone payment receivable upon initiation of IND enabling toxicology study                             $ 15,000,000.0      
2018 Merck Agreement | Future Services on Collaboration Joint Steering Committee ("JSC")                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Contingent payment received                                   15,000,000.0
Remaining contingent payment received                                   300,000
Revenue recognized                               300,000    
2018 Merck Agreement | Merck Sharp & Dohme Corp                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Number of target programs | Program                     2              
Initial transaction price                     $ 60,000,000.0              
Upfront payment received                               60,000,000.0    
Contingent payment received                         10,000,000.0          
Milestone payment received                                   2,500,000
Additional milestone payment received                                   7,500,000
Revenue recognized                               $ 600,000   1,900,000
Revenue recognition aggregate contingent payments eligible to receive                                   500,000,000
Milestone method revenue recognition description                               If one or more products from the target program is developed for non-oncology or a single indication, the Company will be eligible for reduced aggregate contingent payments. In addition, the Company is eligible to receive tiered royalties ranging from mid-single digit to low teen percentages on the worldwide sales of any commercial products that may result from the collaboration.    
First Cytokine-Derivative Program | Merck Sharp & Dohme Corp                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Upfront payment received               $ 5,000,000.0                    
Extended research term               1 year                    
Transaction price $ 65,000,000.0             $ 65,000,000.0 $ 60,000,000.0           80,000,000.0      
Constrained variable consideration                 $ 5,000,000.0           15,000,000.0      
2020 Merck Master Services Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         0               0     $ 0   0
MDA Agreement | EMD Serono                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         0               0     0   0
Contingent payment received                   $ 1,500,000         $ 2,000,000.0      
Milestone payment received             $ 1,000,000.0                      
Maximum amount eligible to receive for each product developed                               52,500,000    
2019 EMD Serono Supply Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         $ 0               500,000     500,000   0
Supply Agreement | Vaxcyte, Inc.                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Reimbursements expenses                         4,000,000.0 $ 3,900,000   10,200,000 $ 4,900,000  
Tasly License Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Minimum term of royalties receivable based on annual net sales         10 years                          
Nonrefundable upfront payment receivable         $ 40,000,000.0                         40,000,000.0
Maximum potential payments related to development regulatory commercialization contingent payments and milestones       $ 350,000,000.0 345,000,000                         345,000,000
Reduction of research and development expenses recognized                         0     0    
Upfront payment revenue not recognized         40,000,000.0                          
Initial licensing payment due       25,000,000.0                            
Initial licensing payment in escrow       $ 15,000,000.0                            
Upfront payment revenue recognized                               25,000,000.0    
Upfront payment withholding tax amount                               2,500,000    
Astellas License and Collaboration Agreement                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Deferred revenue         $ 0               88,100,000     88,100,000   $ 0
Number of target programs | Program     3                              
Upfront payment received                               90,000,000.0    
Transaction price     $ 90,000,000.0                              
Estimated service period     4 years                              
Recognition of up front payment     $ 89,100,000                              
Upfront payment revenue not recognized                               29,200,000    
Nonrefundable, non-creditable upfront payment receivable                         90,000,000.0     90,000,000.0    
Number of performance obligations | PerformanceObligation     4                              
Maximum amount eligible to receive for development, regulatory and commercial milestones for each product candidate                         $ 422,500,000     $ 422,500,000    
Termination written notice period     30 days                              
Astellas License and Collaboration Agreement | Future Services on Collaboration Joint Steering Committee ("JSC")                                    
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                    
Recognition of up front payment     $ 900,000