Quarterly report pursuant to Section 13 or 15(d)

Collaboration and License Agreements and Supply Agreements - Additional Information (Details)

v3.22.2
Collaboration and License Agreements and Supply Agreements - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Mar. 31, 2021
USD ($)
May 31, 2019
USD ($)
Jun. 30, 2022
USD ($)
Program
PerformanceObligation
Apr. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Oct. 31, 2021
USD ($)
Aug. 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Feb. 29, 2020
USD ($)
Sep. 30, 2019
USD ($)
Jul. 31, 2018
USD ($)
Program
Aug. 31, 2017
Program
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Accounts receivable, reserve for credit losses     $ 0   $ 0               $ 0   $ 0   $ 0
Accounts receivable     97,671,000   12,454,000               97,671,000   97,671,000   12,454,000
BioNova Option Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     4,000,000.0                   4,000,000.0   4,000,000.0    
Initial licensing option payment           $ 4,000,000.0                      
Maximum potential payments related to option exercise, development, regulatory, and commercial milestones           $ 200,000,000                      
Minimum term of royalties receivable based on annual net sales           10 years                      
Initial licensing option refundable payment           $ 4,000,000.0                      
Additional payment required to exercise license option           $ 12,000,000.0                      
BMS Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Number of programs advancing through preclinical development | Program                       4          
Contingent payments   $ 275,000,000.0                              
Deferred revenue     0   0               0   0   0
2018 BMS Master Services Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     2,000,000.0   600,000               2,000,000.0   2,000,000.0   600,000
2018 Merck Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     0   900,000               0   0   900,000
Milestone payment receivable upon initiation of IND enabling toxicology study                           $ 15,000,000.0   $ 15,000,000.0  
2018 Merck Agreement | Future Services on Collaboration Joint Steering Committee ("JSC")                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Contingent payment received                                 15,000,000.0
Remaining contingent payment received                                 300,000
Revenue recognized                             300,000    
2018 Merck Agreement | Merck Sharp & Dohme Corp                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Number of target programs | Program                     2            
Initial transaction price                     $ 60,000,000.0            
Upfront payment received                             60,000,000.0    
Milestone payment received                                 2,500,000
Additional milestone payment received                                 7,500,000
Revenue recognized                             $ 600,000   1,900,000
Revenue recognition aggregate contingent payments eligible to receive                                 500,000,000
Milestone method revenue recognition description                             If one or more products from the target program is developed for non-oncology or a single indication, the Company will be eligible for reduced aggregate contingent payments. In addition, the Company is eligible to receive tiered royalties ranging from mid-single digit to low teen percentages on the worldwide sales of any commercial products that may result from the collaboration.    
First Cytokine-Derivative Program | Merck Sharp & Dohme Corp                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Upfront payment received               $ 5,000,000.0                  
Extended research term               1 year                  
Transaction price $ 65,000,000.0             $ 65,000,000.0 $ 60,000,000.0         80,000,000.0      
Constrained variable consideration                 $ 5,000,000.0         15,000,000.0      
2020 Merck Master Services Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     0   0               0   $ 0   0
MDA Agreement | EMD Serono                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     0   0               0   0   0
Contingent payment received                   $ 1,500,000       2,000,000.0      
Milestone payment received             $ 1,000,000.0                    
Maximum amount eligible to receive for each product developed                             52,500,000    
2019 EMD Serono Supply Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     500,000   $ 0               500,000   500,000   0
Supply Agreement | Vaxcyte, Inc.                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Reimbursements expenses                         3,800,000 $ 700,000 6,200,000 $ 1,000,000.0  
Tasly License Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Minimum term of royalties receivable based on annual net sales         10 years                        
Nonrefundable upfront payment receivable         $ 40,000,000.0                       40,000,000.0
Maximum potential payments related to development regulatory commercialization contingent payments and milestones       $ 350,000,000.0 345,000,000                       $ 345,000,000
Reduction of research and development expenses recognized                         0   0    
Upfront payment revenue not recognized         $ 40,000,000.0                        
Initial licensing payment due       25,000,000.0                          
Initial licensing payment in escrow       $ 15,000,000.0                          
Upfront payment revenue recognized                         25,000,000.0   25,000,000.0    
Upfront payment withholding tax amount                         2,500,000   2,500,000    
Astellas License and Collaboration Agreement                                  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                  
Deferred revenue     $ 90,000,000.0                   90,000,000.0   90,000,000.0    
Number of target programs | Program     3                            
Transaction price     $ 90,000,000.0                            
Estimated service period     4 years                            
Revenue recognized                         0   0    
Upfront payment revenue not recognized     $ 90,000,000.0                            
Nonrefundable, non-creditable upfront payment receivable     $ 90,000,000.0                   90,000,000.0   90,000,000.0    
Number of performance obligations | PerformanceObligation     4                            
Maximum amount eligible to receive for development, regulatory and commercial milestones for each product candidate     $ 422,500,000                   $ 422,500,000   $ 422,500,000    
Termination written notice period     30 days