Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity - Schedule of Common Stock Reserved for Future Issuance (Details)

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Stockholders' Equity - Schedule of Common Stock Reserved for Future Issuance (Details) - shares
Dec. 31, 2021
Dec. 31, 2020
Stockholders Equity [Line Items]    
Reserved common stock 11,221,420 8,331,103
Common Stock Options Issued and Outstanding    
Stockholders Equity [Line Items]    
Reserved common stock 6,512,086 5,439,295
Common Stock Awards Issued and Outstanding    
Stockholders Equity [Line Items]    
Reserved common stock 2,403,826 666,375
Remaining Shares Reserved for Issuance under 2018 Equity Incentive Plan and 2021 Equity Inducement Plan    
Stockholders Equity [Line Items]    
Reserved common stock 1,504,641 1,710,824
Shares Reserved for Issuance Under 2018 Employee Stock Purchase Plan    
Stockholders Equity [Line Items]    
Reserved common stock 673,251 361,539
Warrants to Purchase Common Stock    
Stockholders Equity [Line Items]    
Reserved common stock 127,616 153,070