Annual report pursuant to Section 13 and 15(d)

Collaboration and License Agreements and Supply Agreements - Additional Information (Details)

v3.22.0.1
Collaboration and License Agreements and Supply Agreements - Additional Information (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Oct. 31, 2021
USD ($)
Aug. 31, 2020
USD ($)
Mar. 31, 2020
USD ($)
Feb. 29, 2020
USD ($)
Sep. 30, 2019
USD ($)
May 31, 2019
USD ($)
Jul. 31, 2018
USD ($)
Program
Aug. 31, 2017
Program
Jun. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Accounts receivable, reserve for credit losses   $ 0                   $ 0  
BioNova Option Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue   4,000,000.0                   4,000,000.0  
Initial licensing option payment     $ 4,000,000.0                    
Maximum potential payments related to option exercise, development, regulatory, and commercial milestones     $ 200,000,000                    
Minimum term of royalties receivable based on annual net sales     10 years                    
Initial licensing option refundable payment     $ 4,000,000.0                    
Additional payment required to exercise license option     $ 12,000,000.0                    
2019 EMD Serono Supply Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue   0                   0 $ 1,000,000
BMS Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Number of programs advancing through preclinical development | Program                   4      
Contingent payments               $ 275,000,000.0          
Deferred revenue   0                   0 0
2018 BMS Master Services Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue   600,000                   600,000 1,200,000
2018 Merck Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue   900,000                   900,000 18,500,000
Milestone payment receivable upon initiation of IND enabling toxicology study                     $ 15,000,000.0    
2018 Merck Agreement | Merck Sharp & Dohme Corp                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Milestone payment received                       2,500,000  
Additional milestone payment received                       7,500,000  
Number of target programs | Program                 2        
Initial transaction price                 $ 60,000,000.0        
Upfront payment received                       60,000,000.0  
Constrained variable consideration                       7,500,000  
Revenue recognized                       1,900,000  
Revenue recognition aggregate contingent payments eligible to receive                       $ 500,000,000  
Milestone method revenue recognition description                       If one or more products from the target program is developed for non-oncology or a single indication, the Company will be eligible for reduced aggregate milestone payments. In addition, the Company is eligible to receive tiered royalties ranging from mid-single digit to low teen percentages on the worldwide sales of any commercial products that may result from the collaboration  
2018 Merck Agreement | Accounting Standards Update 2014-09 | Merck Sharp & Dohme Corp                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Total interest of unearned revenue   7,300,000                   $ 7,300,000  
2018 Merck Agreement | Future Services on Collaboration Joint Steering Committee ("JSC")                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Contingent payment received                       15,000,000.0  
Remaining contingent payment received                       300,000  
First Cytokine-Derivative Program | Merck Sharp & Dohme Corp                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Upfront payment received         $ 5,000,000.0                
Extended research term         1 year                
Transaction price $ 65,000,000.0       $ 65,000,000.0 $ 60,000,000.0         80,000,000.0    
Constrained variable consideration           $ 5,000,000.0         15,000,000.0    
2020 Merck Master Services Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Deferred revenue   0                   0 0
MDA Agreement | EMD Serono                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Contingent payment received             $ 1,500,000       $ 2,000,000.0    
Milestone payment received       $ 1,000,000.0                  
Deferred revenue   $ 0                   0 0
Maximum amount eligible to receive for each product developed                       52,500,000  
Supply Agreement | Vaxcyte, Inc.                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Reimbursements expenses                       8,900,000 $ 500,000
Tasly License Agreement                          
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                          
Minimum term of royalties receivable based on annual net sales   10 years                      
Nonrefundable upfront payment receivable   $ 40,000,000.0                   40,000,000.0  
Maximum potential payments related to development regulatory commercialization contingent payments and milestones   345,000,000                   345,000,000  
Reduction of research and development expenses recognized                       $ 0  
Upfront payment revenue not recognized   $ 40,000,000.0