Quarterly report pursuant to Section 13 or 15(d)

Equity Incentive Plans, Equity Inducement Plans, Employee Stock Purchase Plan and Stock-Based Compensation (Tables)

v3.23.1
Equity Incentive Plans, Equity Inducement Plans, Employee Stock Purchase Plan and Stock-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]  
Summary of Option Activity

The following table summarizes option activity under the Company’s 2004 Plan, 2018 Plan and 2021 Plan:

 

 

 

Shares

 

 

Weighted-
Average
Exercise Price

 

Stock options outstanding at December 31, 2022

 

 

7,310,611

 

 

$

12.68

 

Granted

 

 

1,118,000

 

 

 

5.78

 

Exercised

 

 

(53,060

)

 

 

5.92

 

Canceled and forfeited

 

 

(38,952

)

 

 

12.35

 

Stock options outstanding at March 31, 2023

 

 

8,336,599

 

 

 

11.80

 

Stock options exercisable at March 31, 2023

 

 

5,386,257

 

 

$

13.04

 
Summary of Status and Activity of Non-vested RSUs

A summary of the status and activity of non-vested RSUs during the three months ended March 31, 2023 is as follows:

 

 

 

Number of
shares

 

 

Weighted
Average
Grant-Date
Fair Value

 

Non-vested December 31, 2022

 

 

3,958,478

 

 

$

11.70

 

Granted

 

 

2,223,725

 

 

 

5.82

 

Vested and released

 

 

(801,769

)

 

 

12.93

 

Canceled and forfeited

 

 

(25,834

)

 

 

13.54

 

Non-vested March 31, 2023

 

 

5,354,600

 

 

$

9.07

 
Schedule of Stock-Based Compensation Expense Recognized

Total stock-based compensation expense recognized was as follows:

 

 

 

Three Months Ended

 

 

 

March 31,

 

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

Research and development expense:

 

$

2,821

 

 

$

2,613

 

General and administrative expense:

 

 

3,200

 

 

 

4,361

 

Total

 

$

6,021

 

 

$

6,974