Quarterly report pursuant to Section 13 or 15(d)

Equity Incentive Plans, Employee Stock Purchase Plan and Stock-Based Compensation - Summary of Option Activity (Details)

v3.22.2.2
Equity Incentive Plans, Employee Stock Purchase Plan and Stock-Based Compensation - Summary of Option Activity (Details) - 2004 Plan, 2018 Plan and 2021 Plan - $ / shares
9 Months Ended
Sep. 30, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]  
Stock options outstanding, Beginning Balance, Shares 6,512,086
Granted, Shares 1,352,500
Exercised, Shares (49,454)
Canceled and forfeited, Shares (341,605)
Stock options outstanding, Ending Balance, Shares 7,473,527
Stock options exercisable, Shares 4,960,812
Stock options outstanding, Weighted - Average Exercise Price, Beginning Balance $ 13.86
Weighted - Average Exercise Price, Granted 7.16
Weighted - Average Exercise Price, Exercised 5.39
Weighted - Average Exercise Price, Canceled and forfeited 14.22
Stock options outstanding, Weighted - Average Exercise Price, Ending Balance 12.69
Stock options exercisable, Weighted - Average Exercise Price, Exercisable $ 13.13